Design, Synthesis of Dioxopiperidinamide Derivatives by Amide Coupling Reaction and Study of Their Biological Activity

A series of fifteen dioxopiperidinamide derivatives synthesized and their spectra chemical data were reported. An alternative amide coupling reaction has been followed by using 3-aminopiperidine-2,6-dione through bond functionalization between N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HCl) Hydroxybenzotriazole (HOBt). All the designed compounds docked in to active sites 2 A73: Human Complement Component C3. is favorable make both hydrogen hydrophobic interaction with amino acids located at binding site. The most potential (E)-N-(2,6-dioxopiperidin-3-yl)-3-(m-tolyl)acrylamide (4 g), (E)-3-(4-bromophenyl)-N-(2,6-dioxopiperidin-3-yl)acrylamide h) N-(2,6-dioxopiperidin-3-yl)-3-methyl-4-oxo-4,6,7,8,9,10-hexahydrothieno [2′,3′:4,5]pyrimido[1,2-a]azepine-2-carboxamide (7) studied for anticancer activity on THP-1 cancer cells line. It was also further established Anti-inflammatory Antioxidant comparable efficiency against those clinically used drugs.